Studies on the Charge-Transfer Interaction Between Tamoxifen Citrate and Chloranilic Acid

نویسندگان

  • Bertrand Akabuogu Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
  • Ekaete Akpabio Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria
  • Godswill Onunkwo Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
  • Paul Akpa Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
  • Petra Nnamani Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
  • Sinyeofori Brown Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria
چکیده مقاله:

      The complex formed as a consequence of the interaction between the electron-acceptor P-chloranilic acid and an electron donor tamoxifen citrate was employed in the assay of the drug in pure powder and tablets. Chloranilic acid was found to form a charge-transfer complex in a 1:1 stoichiometric ratio, with tamoxifen citrate. The wavelength of maximum absorption for the complex was found to be 550 nm while the absorbance was linear over the concentration range of 2-100 g/ml. Evaluations of the various thermodynamic parameters by means of the Scott equation was carried out and were found to decrease with increase in temperature. The free energy change ( G°) and the enthalpy of formation ( H°) as well as the entropy ( S°) were determined for various interactions. Results obtained suggest that the proposed method may be conveniently applied in the analysis of commercially available tamoxifen citrate tablets with a high degree of accuracy and reproducibility.

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studies on the charge-transfer interaction between tamoxifen citrate and chloranilic acid

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عنوان ژورنال

دوره 3  شماره 4

صفحات  203- 208

تاریخ انتشار 2007-10-01

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